Mpox Isn’t Over: What You Need to Know in 2025

Mpox (formerly known as monkeypox) is a viral infection that causes fever, swollen lymph nodes, and a painful rash. While U.S. cases dropped significantly after the 2022–2023 outbreak, mpox remains a global public health emergency, with continued transmission worldwide and low-level spread in the U.S.

As of mid-2025, the U.S. averages about 60 new mpox cases per week, primarily among unvaccinated or partially vaccinated gay, bisexual, and other men who have sex with men. The World Health Organization continues to classify mpox as a Public Health Emergency of International Concern, especially with over 79,000 cases and 578 deaths reported in 23 African countries this year alone.

Vaccination with the JYNNEOS vaccine is strongly encouraged for those at higher risk — including certain LGBTQ+ individuals, people recently diagnosed with STIs, sex workers, and healthcare or lab workers exposed to orthopoxviruses. Early symptom recognition and access to care remain key to prevention.

Mpox may no longer dominate headlines, but it hasn't disappeared. Staying informed and protected is essential in 2025.